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Fetal Origins of Cardiovascular and Lung Disease David J.P. Barker

Fetal Origins of Cardiovascular and Lung Disease

David J.P. Barker

Published September 1st 2000
ISBN : 9780824703912
Hardcover
398 pages
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 About the Book 

This watershed reference presents epidemiological, clinical, and experimental evidence that cardiovascular disease, Type 2 diabetes, and chronic lung disease originate through adaptations to the intrauterine environment. These new findings suggest that major chronic diseases in adult life may be prevented by improving the nutrition of girls and young women to promote healthy fetal development during pregnancy.Focusing on prenatal programming-the process whereby stimuli or insults at critical early periods of life have lasting effects-Fetal Origins of Cardiovascular and Lung Diseasedemonstrates the associations between low birthweight and cardiovascular disease and Type 2 diabetes in adultsreveals the association between prenatal influences and hypertension and asthma in adult lifedescribes pancreatic development in the fetus when the mother is malnourished or experiences metabolic disturbances during pregnancyexamines the effects of undernutrition during gestation in experimental animal modelsdiscusses how the human fetus adapts to variations in maternoplacental nutrient supplydetails fetal influences on lipid metabolism, insulin sensitivity, the somatotrophic axis, andrenarche, and pubarcheand more!Investigating when nurturing begins to influence and modulate gene expression, Fetal Origins of Cardiovascular and Lung Disease is critical for pulmonologists, cardiologists, pediatricians, neonatologists, obstetricians, internists, family practice physicians, and hospital interns and residents.